Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

Table 1 Relevant experimental group characteristics and hemodynamic parameters in the isolated perfused hearts of non-diabetic control, TETA-treated control, diabetic, and TETA-treated diabetic rats

Variable	Control	TETA-control	Diabetic	TETA-diabetic
Strain	Wistar	Wistar	Wistar	Wistar
Sex	Male	Male	Male	Male
Number	9	9	9	9
Age at enrolment (weeks)	6-7	6-7	6-7	6-7
Age when studied (weeks)	22-23	22-23	22-23	22-23
Body weight (g)	573 ± 16	562 ± 17	220 ± 9*	290 ± 21*
Blood glucose (mM)	5.8 ± 0.20	5.1 ± 0.15	29.8 ± 0.65*	27.0 ± 1.20*
Heart weight (g)	1.58 ± 0.04	1.63 ± 0.05	1.03 ± 0.06*	1.18 ± 0.09*
Heart-weight/Body-weight (×10⁻³)	2.76 ± 0.01	2.77 ± 0.13	4.66 ± 0.13*	4.08 ± 0.17*^#
Cardiac output (ml/min)	79.2 ± 3.2	75.0 ± 3.5	53.3 ± 8.1*	78.0 ± 4.0^#
LV + dP/dt max (mmHg/s)	4506 ± 549	4667 ± 417	2249 ± 162*	4082 ± 196^#
LV -dP/dt min (mmHg/s)	−4384 ± 453	−4245 ± 413	−1952 ± 144*	−3366 ± 125^#

Measurements of steady-state cardiac function were made at 20 cm-H₂O preload and 75 mmHg afterload of hearts paced at 300 beats/min. Values are means ± SEM. Data were analyzed using two-way ANOVA with post-hoc Tukey’s tests: *P < 0.05 vs control; ^#P < 0.05 vs diabetic.

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