Figure 6

Effect of chronic treatment with CAPA and insulin on the vascular response. (A) The basal coronary arterial flow rate (mL/min) in retrograde-perfused hearts was measured to evaluate the effect of CAPA in type 1 diabetic rats. The animals were divided into 4 groups and intraperitoneally administered CAPA twice daily for 4 weeks. Control: age- and sex-matched normal rats, n = 6. STZ-veh: vehicle-treated diabetic rats, 0.1 mL/kg DMSO, n = 4. STZ-insulin: insulin-treated diabetic rats, 1 IU/kg, n = 4. STZ-CAPA: CAPA-treated diabetic rats, 3 mg/kg, n = 5. ^*,#P < 0.05 compared with control groups and STZ-induced diabetic rats treated with vehicle. (B) Effect of CAPA on the phenylephrine-induced aortic constriction of type 1 diabetic rat aorta. The effect of CAPA on the phenylephrine-induced aortic contraction response (mN) of STZ-induced type 1 diabetic rat thoracic aorta was measured in isolated aortic strips. The animals were divided into 4 groups. Control: age- and sex-matched normal rats, n = 4. STZ-veh: vehicle-treated diabetic rats, 0.1 mL/kg DMSO, n = 4. STZ-Ins: insulin-treated diabetic rats, 1 IU/kg, n = 4. STZ-CAPA: CAPA-treated diabetic rats, 3 mg/kg, n = 6. ^*,#P < 0.05 compared with control and STZ-veh groups.