Figure 4From: Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic ratsConcentration-dependent inhibition of CAPA on thoracic aorta, constriction-induced by high concentration potassium or phenylephrine. The relaxation effect of CAPA was measured in endothelium-intact (+EC) and endothelium-denuded (−EC) thoracic aorta. The aortic strips were pre-constricted with high concentration of potassium (80 mM) (A) or 1 μM phenylephrine (B), pre-treated with inhibitors (C), such as 10 μM NOS inhibitor (l-NAME), 10 μM nitric oxide-sensitive guanylyl cyclase selective inhibitor (ODQ), and 100 μM soluble guanylyl cyclase inhibitor (MB), and CAPA was added in a cumulated concentrations in the organ bath to assess relaxation effects. The IC50 values for CAPA are shown in (D). Data (mean ± SEM) were obtained from 6–8 animals.Back to article page