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Table 3 HbA 1c -values and measures of HbA 1c -variability

From: Hemoglobin A1c variability as an independent correlate of cardiovascular disease in patients with type 2 diabetes: a cross-sectional analysis of the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study

Variable

n (%)

Current HbA1c, %

HbA1c-MEAN, %

HbA1c-SD, %

HbA1c-CV, %

Adj-HbA1c-SD, %

No CVD

6,157 (74.3)

7.57±1.36

7.63±1.19

0.59±0.48

7.57±5.52

0.52±0.42

7.42 (6.70-8.28)

7.49 (6.81-8.31)

0.46 (0.28-0.73)

6.06 (3.94-9.37)

0.40 (0.26-0.67)

Any coronary event

1,373 (16.6)

7.85±1.34

7.88±1.20

0.60±0.45

7.40±5.13

0.53±0.39

7.70 (6.92-8.57)

7.77 (7.02-8.59)

0.47 (0.29-0.74)

6.18 (3.95-9.22)

0.41 (0.26-0.66)

P

 

<0.0001

<0.0001

0.194

0.821

0.140

Acute myocardial infarction

949 (11.4)

7.80±1.31

7.86±1.18

0.62±0.45

7.64±5.08

0.54±0.39

7.67 (6.92-8.51)

7.78 (7.05-8.53)

0.49 (0.31-0.77)

6.39 (4.13-9.44)

0.43 (0.27-0.67)

P

 

<0.0001

<0.0001

0.004

0.068

0.003

Any cerebrovascular event

902 (10.9)

8,00±1.51

7.96±1.24

0.59±0.45

7.18±4.91

0.52±0.40

7.75 (7.02-8.73)

7.83 (7.12-8.64)

0.47 (0.28-0.72)

5.91 (3.74-8.92)

0.41 (0.25-0.64)

P

 

<0.0001

<0.0001

0.956

0.103

0.672

Stroke

257 (3.1)

7.64±1.37

7.70±1.21

0.59±0.40

7.56±4.86

0.51±0.34

7.45 (6.61-8.43)

7.63 (6.75-8.45)

0.48 (0.30-0.74)

6.28 (4.25-9.40)

0.42 (0.27-0.64)

P

 

0.470

0.354

0.299

0.381

0.325

Any lower limb vascular event

584 (7.0)

8.02±1.45

8.02±1.19

0.64±0.50

7.68±5.34

0.56±0.45

7.85 (7.09-8.73)

7.92 (7.22-8.66)

0.50 (0.31-0.80)

6.32 (4.10-9.38)

0.45 (0.27-0.69)

P

 

<0.0001

<0.0001

0.013

0.372

0.005

Ulceration/gangrene

319 (3.8)

7.93±1.55

8.01±1.25

0.71±0.58

8.49±5.93

0.62±0.51

7.67 (6.98-8.62)

7.88 (7.18-8.64)

0.54 (0.34-0.86)

6.76 (4.31-10.23)

0.48 (0.30-0.76)

P

 

<0.0001

<0.0001

<0.0001

0.004

<0.0001

  1. Current HbA1c, HbA1c-MEAN, HbA1c-SD, HbA1c-CV, and Adj-HbA1c-SD values in patients with any major acute CVD event by vascular bed (coronary, carotid and lower limb) versus subjects without CVD. Values are mean±SD and median (interquartile range); P values for comparison between groups using the Student’s t test for parametric or the corresponding Mann–Whitney U test for nonparametric (HbA1c-SD, HbA1c-CV, and Adj- HbA1c-SD) variables.