Skip to main content

Table 4 Association between HDL genetic risk scores analyzed as a continuous variable and all-cause and CVD-mortality

From: Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study

 

Model 1

Model 2

Model 3

All-cause mortality

HR (CI)

p-value

HR (CI)

p-value

HR (CI)

p-value

Risk score 1a

0.96 (0.91, 1.02)

0.208

0.98 (0.92, 1.03)

0.373

0.97 (0.92, 1.03)

0.295

Risk score 1b

0.96 (0.91, 1.02)

0.175

0.97 (0.92, 1.03)

0.314

0.97 (0.92, 1.02)

0.228

Risk score 2a

0.96 (0.90, 1.03)

0.235

0.97 (0.91, 1.03)

0.302

0.96 (0.90, 1.03)

0.232

Risk score 2b

0.92 (0.87, 0.98)

0.010

0.93 (0.88, 0.99)

0.020

0.93 (0.88, 0.98)

0.011

Combined unweighted

0.96 (0.92- 1.01)

0.115

0.97 (0.93- 1.01)

0.170

0.97 (0.93- 1.01)

0.162

Combined weighted

0.95 (0.91- 0.99)

0.009

0.96 (0.92- 0.99)

0.017

0.95 (0.92- 0.99)

0.011

CVD mortality

      

Risk score 1a

1.00 (0.92, 1.09)

0.958

1.01 (0.93, 1.10)

0.771

1.00 (0.92, 1.09)

0.988

Risk score 1b

1.00 (0.92, 1.09)

0.936

1.01 (0.93, 1.10)

0.880

0.99 (0.91, 1.08)

0.835

Risk score 2a

1.03 (0.93, 1.13)

0.621

1.03 (0.94, 1.13)

0.542

1.02 (0.94, 1.12)

0.622

Risk score 2b

0.96 (0.89, 1.05)

0.407

0.98 (0.90, 1.06)

0.547

0.97 (0.90, 1.05)

0.477

Combined unweighted

1.00 (0.94- 1.07)

0.955

1.01 (0.95- 1.07)

0.826

1.00 (0.94- 1.07)

0.890

Combined weighted

0.98 (0.92- 1.04)

0.429

0.98 (0.93- 1.04)

0.573

0.98 (0.93- 1.04)

0.502

  1. Analysis was performed using Cox proportional hazards regression. Model 1 is unadjusted; Model 2 is adjusted for age and sex; Model 3 is adjusted for age, sex, body mass index, smoking, hypertension, cholesterol medication use, and prior cardiovascular disease. The hazard ratio (HR) and its 95% confidence interval (CI) are reported.