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Table 4 IMD decreases myocardial injury by attenuating inflammatory response

From: Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats

Inflammatory marker(units)/Group

NS

NIR

DS

DIR

IMD

Serum

TNF-α(pg/ml)

65.34 ± 1.49

111.7 ± 3.48†

91.26 ± 2.36

197.9 ± 4.87#

111.9 ± 8.85*

IL-6(pg/ml)

152.2 ± 4.43

287.4 ± 12.44†

183.0 ± 6.23

368.8 ± 12.92#

266.8 ± 20.83*

IL-1(pg/ml)

29.74 ± 1.62

70.09 ± 3.12†

42.86 ± 2.02

97.23 ± 6.14#

60.59 ± 3.87*

Myocardial

TNF-α(Ct)

2.65 ± 0.14

4.35 ± 0.39†

2.88 ± 0.22

5.22 ± 0.33#

3.64 ± 0.49*

 

IL-6(Ct)

1.78 ± 0.81

4.08 ± 0.25†

3.13 ± 0.10

4.47 ± 0.20#

3.18 ± 0.28*

 

IL-1(Ct)

1.71 ± 0.17

3.71 ± 0.29†

2.72 ± 0.26

5.25 ± 0.26#

3.97 ± 0.41*

  1. Abbreviations: NS: non-diabetic sham; NIR: non-diabetic ischemia/reperfusion + vehicle; DS: diabetic sham; DIR: diabetic ischemia/reperfusion + vehicle; IMD: diabetic ischemica/reperfusion group + IMD treatment. Results represent mean ± SEM. †P < 0.05 vs. NS, #P < 0.05 vs. DS, *P < 0.05 vs. DIR. n = 6-12/group.