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Table 3 IMD decreases myocardial injury by attenuating oxidative stress

From: Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats

Marker(units)/Group

NS

NIR

DS

DIR

IMD

MDA (nmol/mg prot)

10.61 ± 0.46

17.33 ± 1.60†

15.77 ± 0.95

26.29 ± 0.71#

19.88 ± 1.31*

SOD U/mg prot)

210.6 ± 9.13

158.0 ± 6.58†

201.4 ± 12.52

133.3 ± 9.55#

184.7 ± 14.39*

NOS (U/g prot)

3.48 ± 0.10

2.77 ± 0.22†

2.99 ± 0.11

1.99 ± 0.14#

2.74 ± 0.22*

NO(umol/g prot)

1.58 ± 0.03

0.85 ± 0.02†

1.34 ± 0.02

0.51 ± 0.04#

0.98 ± 0.02*

p22 phox

1.04 ± 0.12

3.03 ± 0.29†

1.77 ± 0.14

4.97 ± 0.46#

2.63 ± 0.14*

p67 phox

0.92 ± 0.08

3.30 ± 0.24†

2.87 ± 0.15

4.37 ± 0.29#

3.20 ± 0.20*

gP91phox

1.07 ± 0.15

3.25 ± 0.29†

2.41 ± 0.23

5.08 ± 0.28#

3.49 ± 0.43*

  1. Abbreviations: NS: non-diabetic sham; NIR: non-diabetic ischemia/reperfusion + vehicle; DS: diabetic sham; DIR: diabetic ischemia/reperfusion + vehicle; IMD: diabetic ischemica/reperfusion group + IMD treatment. Results represent mean ± SEM. †P < 0.05 vs. NS, #P < 0.05 vs. DS, *P < 0.05 vs. DIR .n = 6-12/group.