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Table 1 Effects of PPARα-agonists on PPAR transcriptional activity

From: Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists

Compound Aleglitazar[26] GFT505[48] K-877[52] Fenofibrate[26, 52]
PPARα EC50 (nM) 5 10 to 20 1 14,000[52]; 22,400[26]
PPARγ EC50 (nM) 9 NA 2,300 ~100,000
PPARδ EC50 (nM) 376 100 to 150 1,000 not activated
  1. EC50 effective concentration inducing 50% response; NA not available.