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Table 1 Effects of PPARα-agonists on PPAR transcriptional activity

From: Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists

Compound

Aleglitazar[26]

GFT505[48]

K-877[52]

Fenofibrate[26, 52]

PPARα

EC50 (nM)

5

10 to 20

1

14,000[52]; 22,400[26]

PPARγ

EC50 (nM)

9

NA

2,300

~100,000

PPARδ

EC50 (nM)

376

100 to 150

1,000

not activated

  1. EC50 effective concentration inducing 50% response; NA not available.
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Cardiovascular Diabetology

ISSN: 1475-2840