Figure 2

Lack of Kir6.2 subunits deteriorates cardiac function in mice following LPS treatment (A, representative echocardiograms). Unlike WT mice, Kir6.2^−/− mice failed to augment cardiac performance 360 min after LPS administration, and progressed to significant depression of ventricular function as determined by left ventricular ejection fraction (EF, B) and fraction of shortening (FS, C). *P<0.05 compared with Control (unpaired t test). Data are expressed as means ± SEM (n=10 per group).