Skip to main content

Table 4 Pharmacokinetic parameters for single empagliflozin doses of 25 mg and 200 mg

From: The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study

Parameter Empagliflozin 25 mg Empagliflozin 200 mg
  gMean % gCV gMean % gCV
AUC 0−tz (nmol∙ hour/L) 4860 16.7 36400 20.0
C max (nmol/L) 768 23.2 4860 22.1
  Median Range Median Range
t max (hours) 1.5 0.5–4.0 1.8 1.0–4.1
  1. AUC0–tz, area under the concentration-time curve of empagliflozin in plasma over the time interval 0–time of the last measurable concentration of empagliflozin in plasma; Cmax, maximum plasma concentration of empagliflozin; and tmax, time to maximum plasma concentration of empagliflozin. Data from the full analysis set analysed per protocol: 25 mg empagliflozin dose group (n=28), 200 mg empagliflozin dose group (n=30). gMean, geometric mean; gCV, geometric coefficient of variance.