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Table 4 Pharmacokinetic parameters for single empagliflozin doses of 25 mg and 200 mg

From: The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study

Parameter

Empagliflozin 25 mg

Empagliflozin 200 mg

 

gMean

% gCV

gMean

% gCV

AUC 0−tz (nmol∙ hour/L)

4860

16.7

36400

20.0

C max (nmol/L)

768

23.2

4860

22.1

 

Median

Range

Median

Range

t max (hours)

1.5

0.5–4.0

1.8

1.0–4.1

  1. AUC0–tz, area under the concentration-time curve of empagliflozin in plasma over the time interval 0–time of the last measurable concentration of empagliflozin in plasma; Cmax, maximum plasma concentration of empagliflozin; and tmax, time to maximum plasma concentration of empagliflozin. Data from the full analysis set analysed per protocol: 25 mg empagliflozin dose group (n=28), 200 mg empagliflozin dose group (n=30). gMean, geometric mean; gCV, geometric coefficient of variance.
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Cardiovascular Diabetology

ISSN: 1475-2840