Figure 6

Dietary capsaicin improves the endothelium-dependent relaxation in db/db mice. A and C: Quantification of the endothelium-dependent relaxation induced by acetylcholine treatment (1 nmol/L to 10 μmol/L) of aortas and mesenteric arteries from db/db mice given either a normal diet (Cont) or a normal diet plus 0.01% capsaicin (Cap) for 14 weeks. Data are expressed as the mean ± SEM from six rings, with six mice per group. *P<0.05, ** P<0.01 versus the db/db control group. B and D: The inhibitory effect of nitro-L-arginine methyl ester (L-NAME, 100 μM, 30min), on acetylcholine-induced maximal relaxation in aortas and mesenteric arteries from db/db mice with or without dietary capsaicin administration. Data are expressed as the mean ± SEM from six rings, with six mice per group. E and F: Representative data showing endothelium-independent relaxation in db/db mouse aortas and mesenteric arteries with or without dietary capsaicin administration. Data are expressed as the mean ± SEM from six rings, with six mice per group.