TRPV1 activation by dietary capsaicin promotes endothelial PKA phosphorylation and increases UCP2 levels in diabetic mice. Representative protein expression of TRPV1 (A and B), p-PKA/PKA (C and D) and UCP2 (E) levels in aorta or mesenteric arteries from db/db mice treated with normal diet (db/db Cont) or normal diet plus 0.01% capsaicin (db/db Cap) and the lean littermate control C57BL/KsJ mice treated with normal diet (WT Cont). Data are mean ± SEM. Each n = 3. ##P <0.01, #P <0.05 versus WT Cont group; *P <0.05 versus db/db Cont group.