Table 2 Association between continuous measures of kidney disease and mortality with covariate adjustment as indicated
Unadjusted | Partially adjusted* | Fully adjusted† | Fully adjusted† + CAC | |||||
|---|---|---|---|---|---|---|---|---|
HR (CI) | p-value | HR (CI) | p-value | HR (CI) | p-value | HR (CI) | p-value | |
All-cause mortality | ||||||||
Serum Albumin | 0.74 (0.65–0.84) | 7.13×10-6 | 0.72 (0.63–0.83) | 3.80×10-6 | 0.71 (0.61–0.82) | 4.02×10-6 | 0.71 (0.61–0.82) | 6.81×10-6 |
Serum Creatinine | 1.56 (1.37–1.80) | 1.53×10-10 | 1.32 (1.12–1.54) | 0.0007 | 1.28 (1.10–1.50) | 0.002 | 1.29 (1.10–1.52) | 0.002 |
UACR | 1.59 (1.43–1.77) | 1.48×10-20 | 1.48 (1.31–1.67) | 1.66×10-10 | 1.41 (1.25–1.59) | 3.95×10-8 | 1.37 (1.22–1.56) | 3.83×10-7 |
eGFR | 0.66 (0.58–0.76) | 2.54×10-9 | 0.76 (0.65–0.89) | 0.0006 | 0.77 (0.66–0.90) | 0.001 | 0.77 (0.65–0.91) | 0.002 |
CVD mortality | ||||||||
Serum albumin | 0.81 (0.66–0.99) | 0.04 | 0.80 (0.65–0.98) | 0.03 | 0.77 (0.62–0.95) | 0.02 | 0.78 (0.63–0.98) | 0.03 |
Serum creatinine | 1.76 (1.42–2.19) | 3.29×10-7 | 1.52 (1.19–1.96) | 0.0009 | 1.44 (1.13–1.84) | 0.003 | 1.48 (1.15–1.91) | 0.003 |
UACR | 1.79 (1.55–2.07) | 4.00×10-15 | 1.65 (1.39–1.95) | 4.74×10-9 | 1.54 (1.29–1.83) | 1.32×10-6 | 1.50 (1.26–1.79) | 5.22×10-6 |
eGFR | 0.62 (0.50–0.77) | 1.08×10-5 | 0.69 (0.54–0.88) | 0.002 | 0.71 (0.56–0.91) | 0.006 | 0.69 (0.53–0.89) | 0.005 |