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Table 2 Association between continuous measures of kidney disease and mortality with covariate adjustment as indicated

From: Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study

  Unadjusted Partially adjusted* Fully adjusted† Fully adjusted† + CAC
  HR (CI) p-value HR (CI) p-value HR (CI) p-value HR (CI) p-value
All-cause mortality
Serum Albumin 0.74 (0.65–0.84) 7.13×10-6 0.72 (0.63–0.83) 3.80×10-6 0.71 (0.61–0.82) 4.02×10-6 0.71 (0.61–0.82) 6.81×10-6
Serum Creatinine 1.56 (1.37–1.80) 1.53×10-10 1.32 (1.12–1.54) 0.0007 1.28 (1.10–1.50) 0.002 1.29 (1.10–1.52) 0.002
UACR 1.59 (1.43–1.77) 1.48×10-20 1.48 (1.31–1.67) 1.66×10-10 1.41 (1.25–1.59) 3.95×10-8 1.37 (1.22–1.56) 3.83×10-7
eGFR 0.66 (0.58–0.76) 2.54×10-9 0.76 (0.65–0.89) 0.0006 0.77 (0.66–0.90) 0.001 0.77 (0.65–0.91) 0.002
CVD mortality
Serum albumin 0.81 (0.66–0.99) 0.04 0.80 (0.65–0.98) 0.03 0.77 (0.62–0.95) 0.02 0.78 (0.63–0.98) 0.03
Serum creatinine 1.76 (1.42–2.19) 3.29×10-7 1.52 (1.19–1.96) 0.0009 1.44 (1.13–1.84) 0.003 1.48 (1.15–1.91) 0.003
UACR 1.79 (1.55–2.07) 4.00×10-15 1.65 (1.39–1.95) 4.74×10-9 1.54 (1.29–1.83) 1.32×10-6 1.50 (1.26–1.79) 5.22×10-6
eGFR 0.62 (0.50–0.77) 1.08×10-5 0.69 (0.54–0.88) 0.002 0.71 (0.56–0.91) 0.006 0.69 (0.53–0.89) 0.005
  1. UACR=urine albumin:creatinine ratio; eGFR=estimated glomerular filtration rate.
  2. *adjusted for age, sex, type 2 diabetes affection status, ACE/ARB medication use; † adjusted for age, sex, type 2 diabetes affection status, body mass index, current smoking, hypertension, dyslipidemia, ACE/ARB medication use, prior cardiovascular disease.