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Table 2 Metformin inhibits fructose and MG-induced intimal SMC migration

From: The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats

Compound

 

Wound closure (%)

 
 

0 h

24 h

48 h

Control

0

28.5 ± 1.3

82.2 ± 5.30**

Fructose (30 mM)

0

54.1 ± 1.8

85.3 ± 1.9**

Fructose (30 mM) + Metformin (10 mM)

0

23.6 ± 1.1

73.6 ± 1.4*

MG (100 μM)

0

83.4 ± 0.9

96.7 ± 1.4*

MG (100 μM) + Metformin (10 mM)

0

22.2 ± 6.5

66.4 ± 6.9*

  1. *P < 0.05 vs. 24 hr, **P < 0.01 vs. 24 hr.
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Cardiovascular Diabetology

ISSN: 1475-2840