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Table 2 Metformin inhibits fructose and MG-induced intimal SMC migration

From: The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats

Compound   Wound closure (%)  
  0 h 24 h 48 h
Control 0 28.5 ± 1.3 82.2 ± 5.30**
Fructose (30 mM) 0 54.1 ± 1.8 85.3 ± 1.9**
Fructose (30 mM) + Metformin (10 mM) 0 23.6 ± 1.1 73.6 ± 1.4*
MG (100 μM) 0 83.4 ± 0.9 96.7 ± 1.4*
MG (100 μM) + Metformin (10 mM) 0 22.2 ± 6.5 66.4 ± 6.9*
  1. *P < 0.05 vs. 24 hr, **P < 0.01 vs. 24 hr.