| Chow control | Fructose diet (60%) | Fructose + Metformin |
---|---|---|---|
Body weight (g) | 514.0 ± 25.4 | 554.0 ± 30.5* | 517.2 ± 15.0†|
Liver weight (g) | 13.8 ± 2.1 | 18.0 ± 1.0 | 14.4 ± 2.2 |
Heart weight (g) | 1.5 ± 0.2 | 2.1 ± 0.3 | 1.6 ± 0.1 |
Kidneys weight (g) | 3.1 ± 0.7 | 4.7 ± 0.9 | 3.3 ± 0.5 |
Mean BP (mmHg) | 94.6 ± 10.9 | 93.1 ± 4.5 | 86.5 ± 9.2 |
Glucose (mmol/L) | 5.80 ± 0.41 | 6.32 ± 0.53* | 5.24 ± 0.69‡ |
Insulin (μg/L) | 0.14 ± 0.02 | 0.55 ± 0.22* | 0.28 ± 0.02†|
Cholesterol (mmol/L) | 3.26 ± 0.22 | 3.97 ± 0.18* | 3.46 ± 0.22†|
HDL-C (mmol/L) | 1.33 ± 0.05 | 1.42 ± 0.23* | 1.48 ± 0.29†|
LDL-C (mmol/L) | 0.97 ± 0.08 | 1.16 ± 0.12 | 0.82 ± 0.15†|
Triglyceride (mmol/L) | 2.10 ± 0.40 | 3.27 ± 1.02** | 2.56 ± 0.75†|
FFA (mmol/L) | 0.77 ± 0.18 | 2.00 ± 0.31** | 1.17 ± 0.22‡ |
MG (nmol/L) | 190.40 ± 52.94 | 513.33 ± 58.29** | 238.00 ± 42.00†|