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Table 1 Effects of metformin on metabolic changes in fructose-induced insulin resistant rats

From: The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats

  Chow control Fructose diet (60%) Fructose + Metformin
Body weight (g) 514.0 ± 25.4 554.0 ± 30.5* 517.2 ± 15.0
Liver weight (g) 13.8 ± 2.1 18.0 ± 1.0 14.4 ± 2.2
Heart weight (g) 1.5 ± 0.2 2.1 ± 0.3 1.6 ± 0.1
Kidneys weight (g) 3.1 ± 0.7 4.7 ± 0.9 3.3 ± 0.5
Mean BP (mmHg) 94.6 ± 10.9 93.1 ± 4.5 86.5 ± 9.2
Glucose (mmol/L) 5.80 ± 0.41 6.32 ± 0.53* 5.24 ± 0.69
Insulin (μg/L) 0.14 ± 0.02 0.55 ± 0.22* 0.28 ± 0.02
Cholesterol (mmol/L) 3.26 ± 0.22 3.97 ± 0.18* 3.46 ± 0.22
HDL-C (mmol/L) 1.33 ± 0.05 1.42 ± 0.23* 1.48 ± 0.29
LDL-C (mmol/L) 0.97 ± 0.08 1.16 ± 0.12 0.82 ± 0.15
Triglyceride (mmol/L) 2.10 ± 0.40 3.27 ± 1.02** 2.56 ± 0.75
FFA (mmol/L) 0.77 ± 0.18 2.00 ± 0.31** 1.17 ± 0.22
MG (nmol/L) 190.40 ± 52.94 513.33 ± 58.29** 238.00 ± 42.00
  1. *P < 0.05 vs. Chow control, **P <0.01 Fructose vs. Chow control.
  2. P < 0.05 vs. Fructose, P < 0.01 vs. Fructose.
  3. BP: blood pressure, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein cholesterol, FFA: free fatty acids, MG: methylglyoxal.
  4. Determinations were performed 4 weeks after balloon injury following 4 week high fructose diet.