Figure 3
From: Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta
Effect of ROCK inhibition on Phe-precontraction and relaxation responses in the endo(+) and endo(−) aortic rings. (A) In the presence of 1-μM Y27632, the contractile response to 1-μM Phe stimulation in diabetic (DM) endo(+) aortic rings was markedly less compared to that of without Y27632. (B) The concentration-dependent contractile responses to Phe of diabetic endo- aortic rings, either in the absence or presence of 1-μM Y27632 are overlapped. Data are expressed as mean ± SEM, n = 5-6/group. *P < 0.05 vs. without Y27632 samples (by using student t-test). (C) DM endo(+) exhibited an increased vasodilator sensitivity to Y27632 compared with endo(−) aortic rings.