Skip to main content
Figure 1 | Cardiovascular Diabetology

Figure 1

From: Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta

Figure 1

Effects of diabetes on the structure and contractile function of thoracic aorta. Light microscopy of endothelium-denuded thoracic aorta. Micrographs of the transverse aortic sections in the control group (A), and the diabetic group (B). Note the unchanged internal diameter of the aorta in the diabetic group compared to that of the control (H. E. X4). Masson’s trichrome stained aorta from the control group (C), and the diabetic group (D). Dark dense part tunica media containing mostly smooth muscle cells and elastin, slightly dense part tunica adventisia containing collagen deposition. Trichrome x40. (E) Original traces representing isotonic contraction of phenylephrine (Phe; 1-μM) treated aorta rings from control (top left), L-NAME incubated control (bottom left) and diabetic (top right) and L-NAME incubated diabetic (bottom right) groups. (F) The maximum responses to the Phe. Bars represent mean ± SEM; n = 6–8 aortic rings/group. *P < 0.05 vs. CON (by using ANOVA with Tukey test).

Back to article page