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Table 3 Safety of triptolide treatment

From: Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy

 

Con

TP

DM

DM + TP,L

DM + TP,M

DM + TP,H

ALT, U/l

44.7 ± 13.3

42.2 ± 12.1

72.4 ± 13.5*

76.5 ± 20.1*

84.5 ± 13.6*

89.6 ± 11.5*

AST, U/l

110.0 ± 41.0

114.0 ± 46.1

144.0 ± 59.0

141.2 ± 43.6

167.7 ± 57.3

167.4 ± 60.2

Cr, μmol/l

53.3 ± 13.8

51.5 ± 11.7

56.4 ± 15.4

41.8 ± 13.1

42.6 ± 8.2

40.2 ± 7.4

CK-MB, U/l

593.2 ± 158.1

538.2 ± 234.7

714.7 ± 132.3

322.0 ± 53.3*#

450.2 ± 90.8#

517.4 ± 79.7

  1. TP, L low-dose triptolide (100 μg/kg/day), TP, M medium-dose triptolide (200 μg/kg/day), TP, H high-dose triptolide (400 μg/kg/day). *P < 0.05 versus Con; #P < 0.05 versus DM.
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Cardiovascular Diabetology

ISSN: 1475-2840