Concentration dependent constriction of phenylephrine (%). Concentration dependent contraction of phenylephrine (PE) on thoracic aorta rings obtained from sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD) groups. Tension is expressed as % relaxation on initial contraction with PE. Values are expressed as mean ±SEM. ‡ Significantly different from sedentary diabetic rats (p<0.05). Significantly different from trained diabetic rats (p<0.05).