From: AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ
Total cholesterol (mmol/l) | Fasting blood glucose (mmol/l) | Change in body weight (%) | Systolic BP (mmHg) | Heart rate (beats/min) | |
---|---|---|---|---|---|
Diabetic ApoE−/− | |||||
Vehicle (n = 8) | 29 ± 3*,# | 23 ± 1*,# | −5,2 ± 0.5*,# | 124 ± 4# | 992 ± 32* |
Telmisartan (n = 8) | 31 ± 5* | 19 ± 1* | −6,9 ± 0.3* | 132 ± 9 | 710 ± 91 |
Telmi + GW9662 (n = 7) | 48 ± 7*‡ | 22 ± 0.5* | −3.4 ± 0.6* | 124 ± 5 | 887 ± 66* |
GW9662 (n = 7) | 72 ± 12*,#,‡ | 32 ± 1*,#,‡ | −12.4 ± 0.6*,#,‡ | 123 ± 7# | 1040 ± 55*,# |
Diabetic ApoE/AT1−/− | |||||
Vehicle (n = 6) | 15 ± 5* | 12 ± 1* | 12.6 ± 0.7* | 106 ± 2 | 884 ± 70 |
GW9662 (n = 6) | 17 ± 3* | 19 ± 2*,# | −5.9 ± 0.9*,# | 106 ± 4 | 772 ± 38 |
Non-diabetic ApoE−/− | |||||
Vehicle (n = 8) | 20 ± 2 | 5 ± 0.2 | 46 ± 0.8 | 123 ± 3 | 649 ± 38 |
Telmisartan (n = 8) | 21 ± 3 | 5 ± 0.4 | 40 ± 0.3 | 118 ± 4 | 727 ± 21 |
Telmi + GW9662 (n = 8) | 22 ± 2 | 5 ± 0.3 | 42 ± 0.5 | 125 ± 4 | 708 ± 42 |
GW9662 (n = 8) | 18 ± 1 | 4 ± 0.4 | 48 ± 0.3 | 131 ± 3 | 695 ± 13 |
Non-diabetic ApoE/AT1−/− | |||||
Vehicle (n = 6) | 8 ± 3 | 5 ± 1 | 47 ± 0.6 | 102 ± 5* | 742 ± 46 |
GW9662 (n = 6) | 8 ± 3 | 4 ± 1 | 50 ± 0.5 | 105 ± 5* | 679 ± 50 |