Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment

Table 4 Summary of analysis by linear mixed-effects modelling of the time-dependent effects of trientine treatment between Weeks 8 and 16 on indexes of cardiac function in diabetic cardiomyopathy

Variable	Treatment	Week	Treatment:Week
Body-weight (g)	NS	NS	0.035
Blood glucose (mM)	NS	NS	NS
Heart rate (bpm)	0.098	NS	NS
LVM (g)	0.023	NS	0.046
LVM/BW	0.096	0.0057	0.0077
CO (ml/min)	0.0009	NS	< 0.0001
CO/LVM (ml/min.mg)	0.0001	0.0003	< 0.0001
LVEF (%)	< 0.0001	< 0.0001	< 0.0001
LVEDV (μl)	0.018	0.0003	0.0091
LVEDV/LVM (μl/mg)	0.0041	NS	0.0013
LVESV (μl)	0.0013	< 0.0001	< 0.0001
LVESV/LVM (μl/mg)	< 0.0001	< 0.0001	< 0.0001
Stroke Vol (μl)	< 0.0001	0.10	< 0.0001
Stroke Vol/LVM (μl/mg)	< 0.0001	0.0002	< 0.0001

Numbers are P- values derived from the fitting of LME models of the general form (Variable ~ [treatment + week + treatment:week]) for each of the indicated variables, wherein individual rats were considered to generate random effects. Abbreviations: bpm, beats per minute; NS, not significant; Treatment:Week, treatment-week interaction term.

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