Table 1 Relevant characteristics and between-group comparisons at baseline (Week 0)
Variable | Control (SHAM) | Diabetic (DIA) | TETA-treated Diabetic (TETA-DIA) | P- value†|
|---|---|---|---|---|
Strain | Wistar | Wistar | Wistar | - |
Age (weeks) | 6-7 | 6-7 | 6-7 | - |
Number (% male)* | 12 (100) | 12 (100) | 13 (100) | - |
Body-weight (g) | 271 (255–287) | 280 (257–302) | 255 (239–271) | NS |
Blood glucose (mM) | 5.1 (4.9-5.2) | 6.0 (5.7-6.3) a | 6.7 (5.9-7.5) a | < 0.001 |
Heart rate (bpm) | 380 (370–389) | 376 (364–388) | 393 (381–401) | 0.059 |
LVM (mg) | 569 (525–614) | 566 (521–610) | 528 (493–562) | NS |
LVM/BW (mg/g) | 2.12 (1.89-2.35) | 2.04 (1.87-2.22) | 2.08 (1.95-2.21) | NS |
CO (ml/min) | 133 (120–146) | 139 (125–152) | 137 (130–140) | NS |
CO/BW (ml/min.g) | 0.50 (0.44-0.55) | 0.50 (0.43-0.58) | 0.54 (0.50-0.59) | NS |
CO/LVM (ml/min.mg) | 0.24 (0.21-0.26) | 0.25(0.23-0.26) | 0.26(0.24-0.29) | NS |
LVEF (%) | 72.2 (69.6-74.9) | 74.7 (72.9-76.5) | 73.4 (71.4-75.5) | NS |
LVEDV (μl) | 485 (446–525) | 494 (440–549) | 476 (456–496) | NS |
LVEDV/LVM (μl/mg) | 0.86 (0.78-0.94) | 0.87 (0.82-0.93) | 0.91 (0.85-0.98) | NS |
LVESV (μl) | 134 (120–149) | 125 (108–143) | 126 (116–136) | NS |
LVESV/LVM (μl/mg) | 0.28 (0.25-0.30) | 0.25 (0.24-0.27) | 0.27 (0.25-0.29) | NS |
Stroke Vol (μl) | 352 (317–386) | 369 (329–410) | 350 (330–370) | NS |
Stroke Vol/LVM (μl/mg) | 0.62 (0.56-0.69) | 0.65 (0.61-0.70) | 0.67 (0.61-0.73) | NS |