Figure 5

Urine production and tissue hydration. A. Urine volumes collected during the experiment and in bladder after euthanization of the animal (t = 35 min). *, P < 0.05 versus C57Bl/6 mice. B. Dry-to-wet weight ratios. Heart and kidneys were collected after the experiment and their wet weight measured, after which organs were stored at 70°C for three days, and then weighed again for obtaining dry weight. *, P < 0.05 versus C57Bl/6 mice; #, P < 0.05 metformin versus control db/db.