Figure 4

Vascular clearance and urine appearance of dextrans. A. Left. Calculated amount of 70 (Dex70) and 40 kDa dextran (Dex40) cleared from the circulation after injection (t = 0 min) until the last time point of blood sampling (t = 30 min). Right: cleared amount of Dex70 divided by Dex40. *, P < 0.05 versus C57Bl/6 mice; #, P < 0.05 metformin versus control db/db. B. Left. Measured amount of dextran in urine collected during the experiment and in bladder after euthanization of the animal (t = 35 min). Right: urine amount of Dex70 divided by Dex40. *, P < 0.05 versus C57Bl/6 mice.