Figure 3

Systemic (glycocalyx excluded) distribution volumes. A: systemic volumes of distribution (normalized to body weight) of circulating blood, i.e., the sum of red blood cell (RBC) and plasma volume (derived from RBC space and hematocrit), and 70 (Dex70) (both n = 5 per group) and 40 kDa dextrans (Dex40) (n = 10 per group). *, P < 0.05 versus C57Bl/6 mice. B: whole-body glycocalyx volumes for circulating plasma and Dex70 (both n = 5 per group), calculated from the difference between their respective distribution volume versus that of Dex40. *, P < 0.05 versus C57Bl/6 mice; #, P < 0.05 metformin versus control db/db.