Figure 1

Body weights and blood glucose levels. Top: body weight was measured every week in the db/db mice (n = 20). The first measurement (week 1) was at an age of 6 weeks. One week later the control group (n = 10) continued with normal drinking water while the experimental group (n = 10) started with the metformin in the water for two weeks until the acute experiment (week 4). C57Bl/6 mice (n = 10) were used as reference group in the acute experiment. Bottom: blood glucose in the db/db mice was measured one week before and one week after start of the metformin, as well as during the acute experiment. The sharp rise in glucose during the acute experiment is likely explained by the anesthetic conditions.