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Table 1 Anthropometric data, blood chemistry and lipoprotein metabolism data in healthy participants with low plasma HDL-C vs. high plasma HDL-C concentration

From: Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

  Low HDL High HDL P
Gender 21 men/16 women 20 men/16 women  
Age (year) 37 ± 11 45 ± 14 0.022
BMI (Kg/m2) 24.0 ± 2.4 23.5 ± 3.3  
Waist (cm) 80 ± 9 80 ± 9  
Glucose (mg/dL) 83 ± 8 84 ± 8  
Insulin (μU/mL) 6.5 ± 3.1 4.4 ± 1.8 <0.001
HOMA index 1.35 ± 0.67 0.91 ± 0.39 0.001
Triglycerides (mg/dL) 97 ± 33 71 ± 34 0.002
Cholesterol (mg/dL) 159 ± 25 186 ± 30 <0.001
HDL-C (mg/dL) 34 ± 4 79 ± 13 <0.001
LDL-C (mg/dL) 106 ± 22 93 ± 22 0.018
VLDL (mg/dL) 19 ± 7 14 ± 7 0.001
TG/HDL ratio 3.00 ± 1.32 0.91 ± 0.42 <0.001
Apo AI (mg/dL) 84.8 ± 15.5 124.9 ± 19.4 <0.001
Apo B (mg/dL) 75.4 ± 21.7 71.8 ± 17.1  
Apo CII (mg/dL) 3.1 ± 1.9 3.1 ± 1.5  
Apo CIII (mg/dL) 7.3 ± 3.1 6.7 ± 4.4  
Apo E (mg/dL) 2.1 ± 0.8 3.2 ± 1.2 <0.001
ALT (U/L) 24 ± 16 16 ± 5 0.005
AST (U/L) 20 ± 6 19 ± 3  
hsCRP (mg/L) 1.7 ± 2.0 2.1 ± 4.6  
SAA (mg/L) 3.2 ± 2.8 6.4 ± 10.5  
CETP (%CE) 13.6 ± 5.3 13.5 ± 4.5  
PLTP (nmolPC/mL/h) 6,247 ± 1,851 6,439 ± 1,617  
LCAT (%CE) 3.71 (2.48-5.02) 2.68 (1.63-3.61) 0.011
LPL (nmFFA/mL/h) 2,403 ± 1,304 4,597 ± 2,616 <0.001
HL (nmFFA/mL/h) 4,517 ± 1,622 3,159 ± 1,424 <0.001
Pre-beta1-HDL (ng/mL) 11.8 ± 5.7 (n = 33) 22.4 ± 22.5 (n = 34) 0.008
  1. ALT, Alanine aminotransferase. Apo, Apolipoprotein. AST, Aspartate aminotransferase. BMI, Body mass index. CETP, Cholesteryl ester transfer protein. HL. Hepatic lipase. HOMA, Homeostasis model assessment. LCAT, Lecithin: cholesterol acyltransferase. LPL, Lipoprotein lipase. hsCPR, C- reactive protein. SAA, Serum amyloid A. PLTP, Phospholipid transfer protein. Student t test, low HDL-C vs. high HDL-C. Data are presented as mean ± SD. P < 0.05. Pre-beta1-HDL (n = 33 low HDL-C; n = 34 high HDL-C). PLTP, HL and LPL (n = 34 low HDL-C; n = 66 high HDL-C).