Table 1 Anthropometric data, blood chemistry and lipoprotein metabolism data in healthy participants with low plasma HDL-C vs. high plasma HDL-C concentration

Gender

21 men/16 women

20 men/16 women

Age (year)

37 ± 11

45 ± 14

0.022

BMI (Kg/m²)

24.0 ± 2.4

23.5 ± 3.3

Waist (cm)

80 ± 9

80 ± 9

Glucose (mg/dL)

83 ± 8

84 ± 8

Insulin (μU/mL)

6.5 ± 3.1

4.4 ± 1.8

<0.001

HOMA index

1.35 ± 0.67

0.91 ± 0.39

0.001

Triglycerides (mg/dL)

97 ± 33

71 ± 34

0.002

Cholesterol (mg/dL)

159 ± 25

186 ± 30

<0.001

HDL-C (mg/dL)

34 ± 4

79 ± 13

<0.001

LDL-C (mg/dL)

106 ± 22

93 ± 22

0.018

VLDL (mg/dL)

19 ± 7

14 ± 7

0.001

TG/HDL ratio

3.00 ± 1.32

0.91 ± 0.42

<0.001

Apo AI (mg/dL)

84.8 ± 15.5

124.9 ± 19.4

<0.001

Apo B (mg/dL)

75.4 ± 21.7

71.8 ± 17.1

Apo CII (mg/dL)

3.1 ± 1.9

3.1 ± 1.5

Apo CIII (mg/dL)

7.3 ± 3.1

6.7 ± 4.4

Apo E (mg/dL)

2.1 ± 0.8

3.2 ± 1.2

<0.001

ALT (U/L)

24 ± 16

16 ± 5

0.005

AST (U/L)

20 ± 6

19 ± 3

hsCRP (mg/L)

1.7 ± 2.0

2.1 ± 4.6

SAA (mg/L)

3.2 ± 2.8

6.4 ± 10.5

CETP (%CE)

13.6 ± 5.3

13.5 ± 4.5

PLTP (nmolPC/mL/h)

6,247 ± 1,851

6,439 ± 1,617

LCAT (%CE)

3.71 (2.48-5.02)

2.68 (1.63-3.61)

0.011

LPL (nmFFA/mL/h)

2,403 ± 1,304

4,597 ± 2,616

<0.001

HL (nmFFA/mL/h)

4,517 ± 1,622

3,159 ± 1,424

<0.001

Pre-beta₁-HDL (ng/mL)

11.8 ± 5.7 (n = 33)

22.4 ± 22.5 (n = 34)

0.008