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Figure 6 | Cardiovascular Diabetology

Figure 6

From: Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes

Figure 6

Anti-oxidant effects of eplerenone in ZDF hearts and HF-stimulated cardiomyocytes. (A) DHE and Mitosox staining (red) in ZDF and ZDF-treated myocardia. Nuclear labelling by DAPI (blue) is also shown. N = 6, each group. (B) By flow cytometry (left), mitosox staining in 0-60 min HF and HF+eplerenone (10-6 M) incubated cardiomyocytes. By immunofluorescence (right), mitosox staining after 10 min of HF stimulation (0.12 mM). (C) ATP production in 12 h HF-stimulated cardiomyocytes. *p < 0.05 and **p < 0.01 vs. control. †p < 0.05 and ††p < 0.01 vs. related ZDF or HF.

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Cardiovascular Diabetology

ISSN: 1475-2840