Measurement of systolic function by echocardiography. Representative M-mode short axis views of Control and STZ + Veh mice at 10 wks of diabetes (A and B, respectively). Ejection fraction (C) and fractional shortening (D) of Control, STZ + Veh, STZ + Alsk, STZ + Benz, STZ + Vals, and STZ + Vals + PD, before STZ treatment and at 10 wks after becoming diabetic. 2 wk values for STZ + Vals + PD are shown, as we could not obtain reliable (before STZ) data in this group. Values are expressed as the mean ± SEM. *P < 0.05 vs. respective Before STZ. #P < 0.05 vs. Control (10wk).