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Table 3 Association of plasma copeptin levels and IMT

From: Plasma copeptin levels are inversely associated with intima-media-thickness in men: the population-based KORA F4 study

 

Copeptin

Copeptin

Copeptin

β per 1 SD increase in copeptin

Q3-4 vs Q1-2

Q4 vs Q1-Q3

Q4 vs Q1

No adjustment

 

All subjects (N = 1,275)

0.010

0.023

0.028

0.005

(-0.005; 0.026)

(0.005; 0.041)

(0.006; 0.050)

(-0.003; 0.013)

Men (N = 624)

-0.013

0.016

0.009

0.002

(-0.036; 0.011)

(-0.011; 0.043)

(-0.024; 0.042)

(-0.010; 0.014)

Women (N = 651)

0.032

0.030

0.046

0.008

(0.012; 0.052)

(0.007; 0.053)

(0.018; 0.074)

(-0.002; 0.018)

Adjusted for age and sex

 

All subjects

-0.018

-0.011

-0.015

-0.001

(-0.030; -0.006)

(-0.025; 0.003)

(-0.033; 0.002)

(-0.007; 0.005)

Men

-0.042

-0.028

-0.038

-0.009

(-0.060; -0.023)

(-0.049; -0.006)

(-0.064; -0.011)

(-0.018; 0.001)

Women

0.005

0.004

0.006

0.005

(-0.011; 0.020)

(-0.013; 0.022)

(-0.016; 0.027)

(-0.002; 0.013)

Adjusted for age, sex and BMI

 

All subjects

-0.018

-0.012

-0.016

-0.002

(-0.030; -0.006)

(-0.026; 0.002)

(-0.033; 0.0005)

(-0.008; 0.004)

Men

-0.039

-0.026

-0.035

-0.009

(-0.057; -0.020)

(-0.048; -0.005)

(-0.061; -0.009)

(-0.018; 0.0002)

Women

0.002

0.002

0.003

0.004

(-0.013; 0.018)

(-0.016; 0.020)

(-0.019; 0.024)

(-0.003; 0.012)

Multivariable adjustment a

 

All subjects

-0.022

-0.014

-0.020

-0.003

(-0.034; -0.010)

(-0.028; -0.0002)

(-0.037; -0.003)

(-0.009; 0.003)

Men

-0.038

-0.024

-0.035

-0.010

(-0.057; -0.020)

(-0.046; -0.002)

(-0.062; -0.009)

(-0.020; -0.001)

Women

-0.002

-0.001

-0.001

0.004

(-0.017; 0.014)

(-0.019; 0.017)

(-0.023; 0.021)

(-0.004; 0.012)

  1. Gender-specific adjusted β’s (95% CI) for IMT given in mm as dependent variable and categories of copeptin as independent variable (highest quartile Q4 or Q3-4 versus lower quartiles (reference)): Results of linear regression models.
  2. aAdjusted for: age, sex, BMI, waist (continuous), hypertension (systolic blood pressure ≥ 140/90 mm Hg or antihypertensive medication), HDL cholesterol (continuous), LDL cholesterol (continuous), triglycerides (continuous), former myocardial infarction or stroke, smoking (active/former/never), alcohol consumption (abstinent/moderate/high), physical activity (high/low), hsCRP, eGFR, prediabetes (yes/no), T2D (yes/no).
  3. bold: p < 0.05.