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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes

Figure 5

ViLVaL combination therapy contributes to maintenance of islet morphology and increases the insulin content of the pancreas. Insulin content was measured in pancreatic extracts (A). The proportion of beta-cells to the whole pancreas was calculated using insulin-stained pancreatic sections (B). Sections of pancreas were immunostained for insulin with glucagon (C to G), PDX-1 (H to L), IRS-2 (with DAPI; M to Q), NF-κB p65 subunits (R to U) or HSP72 (V to Z). Scale bars indicate 20 μm at × 400 magnification. Values represent mean ± SEM, n = 6 – 8. *p < 0.05, **p < 0.01 compared with the CT group. †p < 0.05 compared with the ViL group.

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