Figure 2
From: Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes
Combination treatment with vildagliptin and valsartan improves both insulin resistance and insulin secretion in HFD and db/db mice. Glucose tolerance was evaluated by GTT in HFD (A) or db/db (B) mice. Glucose-stimulated insulin secretion (C) and the insulinogenic index (D) in response to the GTT are shown. Insulin sensitivity was evaluated by ITT in HFD (E) or db/db (F) mice. Values represent mean ± SEM, n = 12 – 14. *p < 0.05, **p < 0.01 compared with the CT group. #p < 0.05 compared with the VaL group. †p < 0.05 compared with the ViL group.