Figure 1

Combination treatment with vildagliptin and valsartan decreases blood glucose in HFD and db/db mice. Weekly food intake (A), body weight increments (B), fasting (C) and random-fed blood glucose (D) were measured during each treatment in HFD or db/db mice. HOMA-IR and HOMA-beta were calculated using fasting blood glucose and insulin levels after 8 weeks of treatment (E and F). Values represent mean ± SEM, n = 12 – 14. *p < 0.05, **p < 0.01 compared with the CT group. †p < 0.05 compared with the ViL group.