Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats

Sárközy, Márta; Zvara, Ágnes; Gyémánt, Nóra; Fekete, Veronika; Kocsis, Gabriella F; Pipis, Judit; Szűcs, Gergő; Csonka, Csaba; Puskás, László G; Ferdinandy, Péter; Csont, Tamás

doi:10.1186/1475-2840-12-16

Cardiovascular Diabetology

Table 1 Down-regulated genes on DNA microarray

From: Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats

Gene function	Description [Gene symbol]	Acc. No.:	AVE log₂	SD	P value	Fold change
Metabolism	Argininosuccinate synthetase [Ass]	NM_013157	−1.33	0.06	0.001	−2.51
	Glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) [Gcat]	NM_001024277	−1.15	0.34	0.006	−2.22
	3-hydroxybutyrate dehydrogenase, type 1 [Bdh1]	NM_053995	−1.14	0.44	0.014	−2.21
	Thymidylate synthase [Tyms]	NM_019179	−0.92	0.08	0.041	−1.89
	Dicarbonyl L-xylulose reductase [Dcxr]	NM_134387	−0.76	0.30	0.015	−1.70
Stress response	Heat shock 70kd protein 1A [Hspa1a]	NM_031971	−1.84	0.48	0.005	−3.59
	Similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) 60 kda heat shock protein [LOC294396]	XR_085659	−1.64	0.24	0.057	−3.11
	Interleukin 18 [il18]	NM_019165	−1.38	0.02	0.007	−2.60
Signal transduction, regulation of transcription	Hairy/anhancer-of-split-related with YRPW motif2 [Hey2]	NM_130417	−1.40	0.15	0.049	−2.64
	Aryl hydrocarbon receptor nuclear translocator-like [Adra1d]	NM_024362	−1.33	0.07	0.001	−2.52
	Activating transcription factor 3 [Atf3]	NM_012912	−1.03	0.26	0.004	−2.05
	RAB7, member RAS oncogene family [Rab7]	NM_023950	−0.98	0.48	0.026	−1.97
	B-cell leukemia/lymphoma 2 related protein A1 [Bcl2a1]	NM_133416	−0.89	0.04	0.019	−1.85
	Sushi, nidogen and EGF-like domains 1 [Sned1]	XM_237415	−0.87	0.51	0.041	−1.83
	Spermatid perinuclear RNA binding protein [Strbp]	NM_053416	−0.87	0.25	0.027	−1.82
	TRAF3 interacting protein 3 [Traf3ip3]	NM_001014132	−0.85	0.25	0.028	−1.81
	Putative bhlh transcription factor (Fragment) [Ascl3]	ENSRNOT00000018309	−0.79	0.15	0.013	−1.73
Membrane proteins, receptors	Atpase, (Na+)/K+ transporting, beta 4 polypeptide [Atp1b4]	NM_053381	−1.38	0.13	0.003	−2.60
	Nerve growth factor receptor (TNFR superfamily, member 16) [Ngfr]	NM_012610	−0.91	0.05	0.027	−1.88
	Cholinergic receptor, nicotinic, gamma polypeptide [Chrng]	NM_019145	−0.99	0.39	0.048	−1.98
	G protein-coupled receptor 37 [Gpr37]	NM_057201	−0.87	0.06	0.030	−1.82
	Adrenergic receptor, alpha 1d [Adra1d]	NM_024483	−0.79	0.43	0.036	−1.73
	Neurotensin receptor 2 [Ntsr2]	NM_022695	−0.77	0.32	0.018	−1.70
Structural protein, cell adhesion	Myosin ixa [myo9a]	NM_134335	−1.26	0.01	0.002	−2.40
	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [St8sia4]	NM_053914	−1.00	0.07	0.032	−2.01
	Similar to collagen, type XXIV, alpha 1 [RGD1565539_predicted]	XM_575056	−1.16	0.03	0.011	−2.24
Others	ADAM metallopeptidase with thrombospondin type 1 motif, 1 [Adamts1]	NM_024400	−2.84	0.90	0.1230	−7.16
	Similar to tatd dnase domain containing 1 [RGD1566244_predicted]	XR_007720	−1.86	0.16	0.038	−3.63
	Aryl hydrocarbon receptor nuclear translocator-like protein [Arntl]	NM_024362	−1.33	0.67	0.001	−2.52
	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Taf13_predicted]	ENSRNOT00000027530	−1.22	0.11	0.039	−2.34
	G protein-coupled receptor 107 [Gpr107_predicted]	ENSRNOT00000037742	−1.18	0.02	0.007	−2.26
	CDK5 regulatory subunit associated protein 1-like 1 [Cdkal1_predicted]	XM_341524	−0.92	0.06	0.041	−1.89
	Similar to chondroitin beta1,4 N-acetylgalactosaminyltransferase 2 [RGD1563660_predicted]	ENSRNOT00000019778	−0.91	0.03	0.017	−1.87
	S100 calcium binding protein A3 [S100a3]	NM_053681	−0.90	0.06	0.028	−1.87
	Similar to TPR repeat-containing protein KIAA1043 [LOC304558]	XM_222260	−0.89	0.08	0.003	−1.85
	Similar to Ten-m4 [Odz4_predicted]	ENSRNOT00000015181	−0.88	0.34	0.047	−1.84
	Kallikrein 14 [Klk14_predicted]	ENSRNOT00000029197	−0.88	0.09	0.047	−1.84
	Mucin 19 [Muc19_predicted]	XM_235593	−0.84	0.33	0.048	1.79
	Copine family member IX [Cpne9]	NM_001024982	−0.84	0.11	0.006	−1.79
	Suppressor of Ty 16 homolog (S. Cerevisiae) [Supt16h_predicted]	XM_223981	−0.81	1.57	0.021	−1.75
	Heterogeneous nuclear ribonucleoprotein L-like [Hnrpll_predicted]	XM_233805	−0.81	0.01	0.008	−1.75
	Cdna clone UI-R-BJ0p-afn-b-03-0-UI 3' [Sln]	CK841541	−0.81	0.30	0.013	−1.75
	Discs, large homolog 4 (Drosophila) [Dlgh4]	NM_019621	−0.80	0.23	0.026	−1.75
	Similar to chondroitin beta1,4 N-acetylgalactosaminyltransferase [RGD1307618_predicted]	XM_224757	−0.80	0.25	0.031	−1.74
	Sterile alpha motif domain containing 4 [Samd4_predicted]	ENSRNOT00000060847	−0.80	0.02	0.012	−1.74
	Similar to RIKEN cdna 1190005B03 [Cdkal1_predicted]	ENSRNOT00000024854	−0.79	0.06	0.035	−1.73
	WDNM1 homolog [LOC360228]	NM_001003706	−0.78	0.24	0.007	−1.72
	CD300 antigen like family member E [Cd300le_predicted]	XR_009489	−0.78	0.362	0.023	−1.71
	Neuronatin [nnat]	NM_053601	−0.77	0.35	0.022	−1.71
	Connective tissue growth factor [Ctgf]	NM_022266	−0.77	0.47	0.049	−1.69
	Chemokine (C-X-C motif) ligand 11 [Cxcl11]	NM_182952	−0.75	0.17	0.003	−1.68

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