Skip to main content
Figure 7 | Cardiovascular Diabetology

Figure 7

From: Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

Figure 7

Determination of cell apoptosis in wild type, ATF6 dn, IRE1 dn and PERK dn cardiomyocytes. (a) the cell apoptosis detected by annexin V and PI double staining by flow cytometry in wild type, ATF dn, IRE1 dn and PERK dn cardiomyocytes exposed to high- glucose incubation. (b) the cell apoptosis detected by annexin V and PI double staining by flow cytometry in wild type, ATF dn, IRE1 dn and PERK dn cardiomyocytes exposed to normal- glucose incubation. (c) The columns in the lower panels show the qualification of apoptotic percentage in the charts in the upper panel. a Values are significantly different from Ctrl; b values are significantly different from NAC; c values are significantly different from DCM. [(&)P < 0.05; (#)P < 0.01; (*)P < 0.001].

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840