Figure 5
Effect of Sitagliptin pre-treatment on in vivo myocardial infarct size. (A) Myocardial infarct size is expressed as a percentage of the risk zone. Sitagliptin pre-treatment reduced myocardial infarct to area at risk ratio (I/R%) in middle aged Wistar and GK rats. There was no difference in myocardial infarct to area at risk ratio in SD or Wistar rats. * P < 0.05:N ≥ 6/group. (B) Representative short axis slices of control and treated hearts depicting non-ischemic zone (blue), area of myocardial infarction (white), and non-infarcted viable myocardium in the area at risk (red).