Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats

Table 4 Basal isolated papillary muscle data

Parameters	SHR (n = 13)	SHR-DM (n = 12)	P value
DT (g/mm²)	5.60 (2.57 – 7.99)	3.05 (2.17 – 5.42)	0.121
RT (g/mm²)	0.92 ± 0.37	0.81 ± 0.27	0.383
TPT (ms)	236 ± 30	264 ± 24	0.024
+dT/dt (g/mm²/s)	43.2 ± 22.5	25.7 ± 15.4	0.033
-dT/dt (g/mm²/s)	19.5 ± 9.54	15.3 ± 6.96	0.229
CSA (mm²)	1.04 ± 0.38	1.13 ± 0.30	0.511

Data are expressed as mean ± standard deviation or median and 25^th and 75^th percentile. SHR: spontaneously hypertensive rats without diabetes mellitus; SHR-DM: SHR with diabetes mellitus; DT: peak developed tension; RT: resting tension; TPT: time to peak tension; +dT/dt: maximum tension development rate; -dT/dt: maximum tension decline rate; CSA: papillary muscle cross sectional area. P value: result of statistical test (Student’s t or Mann-Whitney tests).

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