Plasma activin A levels in men with uncomplicated type 2 diabetes versus controls. (A) Whisker plots (median, min – max) of plasma activin A levels in 78 type 2 diabetic (T2D) men and 14 healthy control men. Differences in plasma activin A levels were analyzed using a Mann–Whitney U-test. Regression analyses showed significant inverse correlation of plasma activin A levels with myocardial metabolic rate of glucose for all subjects, T2D men and control (Co) subjects (MMRglu; B), and positive correlations with left ventricular mass/volume ratio (LVMV-ratio; C), and aortic pulse wave velocity (PWV; D) in T2D men (black dots with black regression line) and controls (white dots with dashed regression line). Grey lines represent pooled regression lines.