|  | Model 2 | Model 2 + LGI | Model 2 + ED |
|---|
|  | Standardised β | 95%-CI | p-value | Standardised β | 95%-CI | p-value | Standardised β | 95%-CI | p-value |
|---|
Pentosidine (SD) | 0.47 | 0.03 – 0.91 | 0.036 | 0.47 | 0.03 – 0.91 | 0.038 | 0.43 | -0.02 – 0.87 | 0.060 |
- Data are presented as standardized β (sβ). A sβ of 0.47 SD indicates that individuals with T1DM with a CAC score of >10 have on average 0.47 SD higher pentosidine levels compared to individuals with a score of 0–10.
- n = 122 for individuals with a calcification score of 0–10; n = 27 for those with a calcification score of >10.
- Model 2 was adjusted for age, sex, SBP, DBP, BMI, WHR, pack-years of smoking, LDL, HDL, triglycerides and eGFR. This model was additionally adjusted for high sensitivity C-reactive protein (hsCRP), a marker for low-grade inflammation (LGI), or for soluble vascular cell adhesion molecule 1 (sVCAM-1) and von Willebrand Factor (vWF), which are markers of endothelial dysfunction (ED).
