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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat

Figure 3

Effect of exendin-4 on infarct size and area at risk following acute myocardial ischemia/reperfusion injury. Sprague–Dawley rats were subjected to 30 min LAD coronary artery occlusion followed by 24 h reperfusion. Hearts were harvested and analyzed for area at risk and infarct size. Representative photographs of heart sections from vehicle, 0.1, 1, 10 μg/kg and 1 μg/kg exendin-4 at Cmin (from left to right) stained by 2,3,5-triphenyltetrazolium chloride (TTC) and Evans blue dye illustrate myocardial infarct (white), area at risk (white and red) and area not at risk (dark blue) (A). Myocardial infarct size was assessed as percentage of area at risk in the left ventricle (B). The area at risk was assessed as percentage of the left ventricle area (C). Values are presented as mean ± SEM. *p < 0.05 and **p < 0.01 vs. vehicle (n = 8-10/group).

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