Figure 2
Rat GAlbudAb and exendin-4 pharmacokinetic analysis and computer simulation for predicting plasma drug concentrations. A, Plasma GAlbudAb concentrations following 1 mg/kg subcutaneous administration and blood samples were collected at 1, 2, 4, 8 and 24 h and plasma exendin-4 concentrations following 10 μg/kg subcutaneous administration and blood samples were collected at 10 min, 30 min, 60 min, 2, 4 and 8 h (n = 3/group). B, Computer simulated GAlbudAb concentration curves at a projected dose of 2 mg/kg, which achieved a sustained exposure above 1000 ng/ml after 48 h and computer simulated exendin-4 concentration curves following 1 μg/kg twice daily SC dosing of exendin-4 for 3 days, which showed exendin-4 was at its Cmin 6 h post dose.