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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Rationale and design of a randomized trial on the impact of aldosterone antagonism on cardiac structure and function in diabetic cardiomyopathy

Figure 1

Proposed scheme of development and progression of cardiac dysfunction as a result of the metabolic abnormalities seen in diabetes. Legend: RAAS = renin–angiotensin II–aldosterone system, PPARs = peroxisome proliferator activator receptors, ER = endoplasmic reticulum, ATP = adenosine triphosphate. From Mandavia CH, Aroor AR, DeMarco VG, Sowers JR: Molecular and metabolic mechanisms of cardiac dysfunction in diabetes. Life sciences 2012, 92:601–608 [9]. Copyright 2012 by Elsevier Inc. Reprinted with permission.

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Cardiovascular Diabetology

ISSN: 1475-2840