| Diabetes model | |||||
---|---|---|---|---|---|---|
(High-fat feeding with low dose STZ) | ||||||
 | Control | 0 mg/kg | 15 mg/kg | 20 mg/kg | 25 mg/kg | 30 mg/kg |
Total body weight gain (g) | 69 ± 3 | 82 ± 7 | 88 ± 15 | 93 ± 5 | 77 ± 9 | 50 ± 9 # |
Body weight change during two weeks of diet modification (g) | 46 ± 1 | 49 ± 7 | 56 ± 12 | 60 ± 2 | 55 ± 8 | 55 ± 7 |
Body weight change in final week following STZ or control (g) | 23 ± 4 | 33 ± 5 | 32 ± 2 | 33 ± 3 | 22 ± 4 | −5 ± 4 *†|
Epidydimal fat pad weight (g) | 4.8 ± 0.4 | 7.0 ± 0.7 | 5.7 ± 0.4 | 7.6 ± 0.7 | 9.8 ± 0.6 *# | 8.3 ± 0.7 * |
Epidydimal fat pad to body weight ratio (%) | 1.5 ± 0.1 | 2.0 ± 0.2 | 1.8 ± 0.1 | 2.4 ± 0.2 * | 2.5 ± 0.1 * | 2.3 ± 0.2 * |
Heart weight (g) | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 |
Heart to body weight ratio (× 103) | 3.6 ± 0.2 | 3.5 ± 0.1 | 3.4 ± 0.2 | 3.4 ± 0.2 | 3.2 ± 0.2 | 3.1 ± 0.1 |