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Table 1 Physical parameters from control and diabetic rats, induced using high-fat feeding in combination with low dose STZ

From: Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

  Diabetes model
(High-fat feeding with low dose STZ)
  Control 0 mg/kg 15 mg/kg 20 mg/kg 25 mg/kg 30 mg/kg
Total body weight gain (g) 69 ± 3 82 ± 7 88 ± 15 93 ± 5 77 ± 9 50 ± 9 #
Body weight change during two weeks of diet modification (g) 46 ± 1 49 ± 7 56 ± 12 60 ± 2 55 ± 8 55 ± 7
Body weight change in final week following STZ or control (g) 23 ± 4 33 ± 5 32 ± 2 33 ± 3 22 ± 4 −5 ± 4 *†
Epidydimal fat pad weight (g) 4.8 ± 0.4 7.0 ± 0.7 5.7 ± 0.4 7.6 ± 0.7 9.8 ± 0.6 *# 8.3 ± 0.7 *
Epidydimal fat pad to body weight ratio (%) 1.5 ± 0.1 2.0 ± 0.2 1.8 ± 0.1 2.4 ± 0.2 * 2.5 ± 0.1 * 2.3 ± 0.2 *
Heart weight (g) 1.2 ± 0.1 1.2 ± 0.1 1.1 ± 0.1 1.1 ± 0.1 1.0 ± 0.1 1.1 ± 0.1
Heart to body weight ratio (× 103) 3.6 ± 0.2 3.5 ± 0.1 3.4 ± 0.2 3.4 ± 0.2 3.2 ± 0.2 3.1 ± 0.1
  1. * p < 0.05 vs. control, † p < 0.05 vs. all other doses of STZ, # p < 0.05 vs. 15 mg/kg STZ. n = 11 for control groups, n = 4 for diabetic groups.