Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

Table 1 Physical parameters from control and diabetic rats, induced using high-fat feeding in combination with low dose STZ

		Diabetes model
		(High-fat feeding with low dose STZ)
	Control	0 mg/kg	15 mg/kg	20 mg/kg	25 mg/kg	30 mg/kg
Total body weight gain (g)	69 ± 3	82 ± 7	88 ± 15	93 ± 5	77 ± 9	50 ± 9 #
Body weight change during two weeks of diet modification (g)	46 ± 1	49 ± 7	56 ± 12	60 ± 2	55 ± 8	55 ± 7
Body weight change in final week following STZ or control (g)	23 ± 4	33 ± 5	32 ± 2	33 ± 3	22 ± 4	−5 ± 4 *†
Epidydimal fat pad weight (g)	4.8 ± 0.4	7.0 ± 0.7	5.7 ± 0.4	7.6 ± 0.7	9.8 ± 0.6 *#	8.3 ± 0.7 *
Epidydimal fat pad to body weight ratio (%)	1.5 ± 0.1	2.0 ± 0.2	1.8 ± 0.1	2.4 ± 0.2 *	2.5 ± 0.1 *	2.3 ± 0.2 *
Heart weight (g)	1.2 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.1 ± 0.1	1.0 ± 0.1	1.1 ± 0.1
Heart to body weight ratio (× 10³)	3.6 ± 0.2	3.5 ± 0.1	3.4 ± 0.2	3.4 ± 0.2	3.2 ± 0.2	3.1 ± 0.1

* p < 0.05 vs. control, † p < 0.05 vs. all other doses of STZ, # p < 0.05 vs. 15 mg/kg STZ. n = 11 for control groups, n = 4 for diabetic groups.

ISSN: 1475-2840