Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus

Table 1 Association between the risk of DR and the combination of the ALDH2 genotypes and the serum GGT levels

GGT levels^†	ALDH2 genotype	n	HR^‡(95% CI)	P-value	HR^‡(95% CI)	P-value
Low	1/1 genotype	58	1	-	-	-
	*2 allele carrier	59	1.60 (0.77 - 4.09)	0.25	-	-
High	1/1 genotype	85	1.15 (0.53 - 2.49)	0.73	1	-
	*2 allele carrier	32	2.63 (1.12-6.18)	0.03	2.45 (1.10-5.48)	0.03

^†GGT was dichotomized by the near-median 37 IU/L for the males and 26 IU/L for the females.
^‡Adjusted by gender, BMI, duration of diabetes, HbA1c and systolic BP.
DR, diabetic retinopathy; ALDH2, aldehyde dehydrogenase 2; GGT, γ-glutamyltransferase; HR, hazard ratio; CI, confidence interval; BMI, body mass index; HbA1c, hemoglobin A1c; BP, blood pressure.

ISSN: 1475-2840