Skip to main content

Table 1 Association between the risk of DR and the combination of the ALDH2 genotypes and the serum GGT levels

From: Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus

GGT levels ALDH2 genotype n HR(95% CI) P-value HR(95% CI) P-value
Low *1/*1 genotype 58 1 - - -
  *2 allele carrier 59 1.60 (0.77 - 4.09) 0.25 - -
High *1/*1 genotype 85 1.15 (0.53 - 2.49) 0.73 1 -
  *2 allele carrier 32 2.63 (1.12-6.18) 0.03 2.45 (1.10-5.48) 0.03
  1. GGT was dichotomized by the near-median 37 IU/L for the males and 26 IU/L for the females.
  2. Adjusted by gender, BMI, duration of diabetes, HbA1c and systolic BP.
  3. DR, diabetic retinopathy; ALDH2, aldehyde dehydrogenase 2; GGT, γ-glutamyltransferase; HR, hazard ratio; CI, confidence interval; BMI, body mass index; HbA1c, hemoglobin A1c; BP, blood pressure.