Baseline and 1-year interim follow-up assessment of Japanese patients initiating insulin therapy who were enrolled in the cardiovascular risk evaluation in people with type 2 diabetes on insulin therapy study: an international, multicenter, observational study

Table 6 Achieved HbA1c Level <7.0%, withdrawal at 1 year, and hypoglycemic episodes by duration of diabetes

	All	<5 years	≥5, <10 years	≥10, <15 years	≥15 years	P ¹⁾
Achievement of HbA1c level <7.0%	193/482 (40.0%)	44/95 (46.3%)	49/120 (40.8%)	50/129 (38.8%)	47/132 (35.6%)	N.S.
Withdrawal from insulin at 1 year	27/488 (5.5%)	9/95 (9.5%)	8/121 (6.6%)	7/129 (5.4%)	3/137 (2.2%)	*
Patients with any hypoglycemic episodes	105/482 (21.8%)	19/95 (20.0%)	17/120 (14.2%)	39/127 (30.7%)	29/134 (21.6%)	N.S.
Number of any hypoglycemic episodes/patient	1.44 ± 5.18	0.84 ± 2.72	1.06 ± 4.81	2.61 ± 7.87	1.11 ± 3.22	N.S.
Patients with severe hypoglycemic episodes	8/483 (1.7%)	2/95 (2.1%)	1/120 (0.8%)	2/128 (1.6%)	3/134 (2.2%)	N.S.
Number of severe hypoglycemic episodes/patient	0.03 ± 0.35	0.03 ± 0.23	0.01 ± 0.09	0.02 ± 0.12	0.07 ± 0.62	N.S.

¹⁾Trend test by Cochran-Armitage test for categorical variables and analysis of variance with contrast statement for numerical variables.
N.S. not statistically significant, *P < .05.

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