Baseline and 1-year interim follow-up assessment of Japanese patients initiating insulin therapy who were enrolled in the cardiovascular risk evaluation in people with type 2 diabetes on insulin therapy study: an international, multicenter, observational study

Table 5 Achieved HbA1c Level <7.0%, withdrawal at 1 year, and hypoglycemic episodes by baseline levels

	All¹⁾	≤8.0%	>8.1%, ≤10.0%	>10.0%, ≤12.0%	>12.0%	P ²⁾
Achievement of HbA1c level <7.0%	193/482 (40.0%)	33/55 (60.0%)	69/189 (36.5%)	60/161 (37.3%)	29/73 (39.7%)	**³⁾
Withdrawal from insulin at 1 year	27/488 (5.5%)	5/55 (9.1%)	7/191 (3.7%)	9/164 (5.5%)	6/74 (8.1%)	N.S.
Patients with any hypoglycemic episodes	105/482 (21.8%)	15/54 (27.8%)	39/189 (20.6%)	34/162 (21.0%)	16/73 (21.9%)	N.S.
Number of hypoglycemic episode/patient	1.44 ± 5.18	1.85 ± 6.43	1.13 ± 3.62	1.56 ± 5.19	1.58 ± 7.23	N.S.
Patients with severe hypoglycemic episodes	8/483 (1.7%)	3/54 (5.6%)	3/190 (1.6%)	1/162 (0.6%)	1/73 (1.4%)	*³⁾
Number of severe hypoglycemic episodes/patients	0.03 ± 0.35	0.17 ± 0.97	0.02 ± 0.18	0.01 ± 0.08	0.01 ± 0.12	**

¹⁾Including patients with missing baseline HbA1c level data.
²⁾Trend test by Cochran-Armitage test for categorical variables and analysis of variance with contrast statement for numerical variables.
³⁾Category score = (2,1,1,1).
N.S. not statistically significant, *P < .05, **P < .01.

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