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Table 1 Cardiovascular parameters in conscious, high-fat fed, C57BL/6 mice

From: Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart

  Baseline 7 days post-MI 28 days post-MI
  SHAM MI + PBS MI + MSC SHAM MI + PBS MI + MSC SHAM MI + PBS MI + MSC
HR (bpm) 647 ± 16 662 ± 16 689 ± 9* 720 ± 8 699 ± 10 713 ± 12 710 ± 11 720 ± 13 731 ± 6
FS (%) 49.58 ± 0.75 48.88 ± 1.02 48.74 ± 0.46 49.12 ± 0.78 29.88 ± 3.16* 30.90 ± 2.03* 48.99 ± 0.70 27.34 ± 2.84* 32.90 ± 2.02*
EF (%) 82.07 ± 0.72 81.37 ± 1.01 81.23 ± 0.45 81.80 ± 0.76 56.51 ± 4.88* 58.48 ± 2.9* 81.48 ± 0.74 52.80 ± 2.93* 61.10 ± 2.88*†
IVSd (mm) 0.77 ± 0.02 0.81 ± 0.02 0.79 ± 0.01 0.76 ± 0.02 0.73 ± 0.04 0.84 ± 0.01*† 0.79 ± 0.01 0.76 ± 0.03 0.85 ± 0.01*†
LVIDd (mm) 3.19 ± 0.07 3.21 ± 0.08 3.28 ± 0.04 3.02 ± 0.04 4.31 ± 0.24* 4.01 ± 0.13* 3.23 ± 0.08 4.32 ± 0.21* 4.27 ± 0.13*
LVPWd (mm) 0.72 ± 0.01 0.69 ± 0.02 0.80 ± 0.02† 0.74 ± 0.02 0.68 ± 0.07 0.86 ± 0.03*† 0.77 ± 0.02 0.71 ± 0.04 0.91 ± 0.03
IVSs (mm) 0.91 ± 0.02 0.91 ± 0.02 0.90 ± 0.01 0.88 ± 0.02 0.87 ± 0.05 0.92 ± 0.02 0.88 ± 0.01 0.84 ± 0.02 0.96 ± 0.01*†
LVIDs (mm) 1.61 ± 0.04 1.65 ± 0.06 1.68 ± 0.03 1.54 ± 0.04 3.06 ± 0.28* 2.79 ± 0.16* 1.65 ± 0.06 3.17 ± 0.26* 2.89 ± 0.17*
LVPWs (mm) 0.97 ± 0.02 0.98 ± 0.04 1.04 ± 0.01 0.88 ± 0.02 0.83 ± 0.09 1.01 ± 0.02*† 0.96 ± 0.02 0.82 ± 0.06* 1.11 ± 0.03*†
  1. Data are mean ± SEM for n = 8-13 mice per group.
  2. *p < 0.05 vs. SHAM at specified time point.
  3. †p < 0.05 vs. MI + PBS at specified time point.
  4. Abbreviations: HR, heart rate; FS, fractional shortening; EF, ejection fraction; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricle (LV) end-diastolic dimension; LVPWd, LV posterior wall thickness in diastole; IVSs, interventricular septal thickness in systole; LVIDs, LV end-systolic dimension; LVPWs, LV posterior wall thickness in systole.
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