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Table 1 Cardiovascular parameters in conscious, high-fat fed, C57BL/6 mice

From: Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart

 

Baseline

7 days post-MI

28 days post-MI

 

SHAM

MI + PBS

MI + MSC

SHAM

MI + PBS

MI + MSC

SHAM

MI + PBS

MI + MSC

HR (bpm)

647 ± 16

662 ± 16

689 ± 9*

720 ± 8

699 ± 10

713 ± 12

710 ± 11

720 ± 13

731 ± 6

FS (%)

49.58 ± 0.75

48.88 ± 1.02

48.74 ± 0.46

49.12 ± 0.78

29.88 ± 3.16*

30.90 ± 2.03*

48.99 ± 0.70

27.34 ± 2.84*

32.90 ± 2.02*

EF (%)

82.07 ± 0.72

81.37 ± 1.01

81.23 ± 0.45

81.80 ± 0.76

56.51 ± 4.88*

58.48 ± 2.9*

81.48 ± 0.74

52.80 ± 2.93*

61.10 ± 2.88*†

IVSd (mm)

0.77 ± 0.02

0.81 ± 0.02

0.79 ± 0.01

0.76 ± 0.02

0.73 ± 0.04

0.84 ± 0.01*†

0.79 ± 0.01

0.76 ± 0.03

0.85 ± 0.01*†

LVIDd (mm)

3.19 ± 0.07

3.21 ± 0.08

3.28 ± 0.04

3.02 ± 0.04

4.31 ± 0.24*

4.01 ± 0.13*

3.23 ± 0.08

4.32 ± 0.21*

4.27 ± 0.13*

LVPWd (mm)

0.72 ± 0.01

0.69 ± 0.02

0.80 ± 0.02†

0.74 ± 0.02

0.68 ± 0.07

0.86 ± 0.03*†

0.77 ± 0.02

0.71 ± 0.04

0.91 ± 0.03

IVSs (mm)

0.91 ± 0.02

0.91 ± 0.02

0.90 ± 0.01

0.88 ± 0.02

0.87 ± 0.05

0.92 ± 0.02

0.88 ± 0.01

0.84 ± 0.02

0.96 ± 0.01*†

LVIDs (mm)

1.61 ± 0.04

1.65 ± 0.06

1.68 ± 0.03

1.54 ± 0.04

3.06 ± 0.28*

2.79 ± 0.16*

1.65 ± 0.06

3.17 ± 0.26*

2.89 ± 0.17*

LVPWs (mm)

0.97 ± 0.02

0.98 ± 0.04

1.04 ± 0.01

0.88 ± 0.02

0.83 ± 0.09

1.01 ± 0.02*†

0.96 ± 0.02

0.82 ± 0.06*

1.11 ± 0.03*†

  1. Data are mean ± SEM for n = 8-13 mice per group.
  2. *p < 0.05 vs. SHAM at specified time point.
  3. †p < 0.05 vs. MI + PBS at specified time point.
  4. Abbreviations: HR, heart rate; FS, fractional shortening; EF, ejection fraction; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricle (LV) end-diastolic dimension; LVPWd, LV posterior wall thickness in diastole; IVSs, interventricular septal thickness in systole; LVIDs, LV end-systolic dimension; LVPWs, LV posterior wall thickness in systole.