| |
Baseline
|
7 days post-MI
|
28 days post-MI
|
|---|
| |
SHAM
|
MI + PBS
|
MI + MSC
|
SHAM
|
MI + PBS
|
MI + MSC
|
SHAM
|
MI + PBS
|
MI + MSC
|
|---|
|
HR (bpm)
|
647 ± 16
|
662 ± 16
|
689 ± 9*
|
720 ± 8
|
699 ± 10
|
713 ± 12
|
710 ± 11
|
720 ± 13
|
731 ± 6
|
|
FS (%)
|
49.58 ± 0.75
|
48.88 ± 1.02
|
48.74 ± 0.46
|
49.12 ± 0.78
|
29.88 ± 3.16*
|
30.90 ± 2.03*
|
48.99 ± 0.70
|
27.34 ± 2.84*
|
32.90 ± 2.02*
|
|
EF (%)
|
82.07 ± 0.72
|
81.37 ± 1.01
|
81.23 ± 0.45
|
81.80 ± 0.76
|
56.51 ± 4.88*
|
58.48 ± 2.9*
|
81.48 ± 0.74
|
52.80 ± 2.93*
|
61.10 ± 2.88*†
|
|
IVSd (mm)
|
0.77 ± 0.02
|
0.81 ± 0.02
|
0.79 ± 0.01
|
0.76 ± 0.02
|
0.73 ± 0.04
|
0.84 ± 0.01*†
|
0.79 ± 0.01
|
0.76 ± 0.03
|
0.85 ± 0.01*†
|
|
LVIDd (mm)
|
3.19 ± 0.07
|
3.21 ± 0.08
|
3.28 ± 0.04
|
3.02 ± 0.04
|
4.31 ± 0.24*
|
4.01 ± 0.13*
|
3.23 ± 0.08
|
4.32 ± 0.21*
|
4.27 ± 0.13*
|
|
LVPWd (mm)
|
0.72 ± 0.01
|
0.69 ± 0.02
|
0.80 ± 0.02†
|
0.74 ± 0.02
|
0.68 ± 0.07
|
0.86 ± 0.03*†
|
0.77 ± 0.02
|
0.71 ± 0.04
|
0.91 ± 0.03
|
|
IVSs (mm)
|
0.91 ± 0.02
|
0.91 ± 0.02
|
0.90 ± 0.01
|
0.88 ± 0.02
|
0.87 ± 0.05
|
0.92 ± 0.02
|
0.88 ± 0.01
|
0.84 ± 0.02
|
0.96 ± 0.01*†
|
|
LVIDs (mm)
|
1.61 ± 0.04
|
1.65 ± 0.06
|
1.68 ± 0.03
|
1.54 ± 0.04
|
3.06 ± 0.28*
|
2.79 ± 0.16*
|
1.65 ± 0.06
|
3.17 ± 0.26*
|
2.89 ± 0.17*
|
|
LVPWs (mm)
|
0.97 ± 0.02
|
0.98 ± 0.04
|
1.04 ± 0.01
|
0.88 ± 0.02
|
0.83 ± 0.09
|
1.01 ± 0.02*†
|
0.96 ± 0.02
|
0.82 ± 0.06*
|
1.11 ± 0.03*†
|
- Data are mean ± SEM for n = 8-13 mice per group.
- *p < 0.05 vs. SHAM at specified time point.
- †p < 0.05 vs. MI + PBS at specified time point.
- Abbreviations: HR, heart rate; FS, fractional shortening; EF, ejection fraction; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricle (LV) end-diastolic dimension; LVPWd, LV posterior wall thickness in diastole; IVSs, interventricular septal thickness in systole; LVIDs, LV end-systolic dimension; LVPWs, LV posterior wall thickness in systole.
