Whole body insulin sensitivity and blood glucose during the hyperinsulinemic-euglycemic (insulin) clamp. (a) Glucose infusion rate (GIR) during the insulin clamp. The GIR is equivalent to the whole body glucose disposal rate in response to venous insulin infusion. The insulin infusion was for approximately 120 minutes prior to 2-[14C]deoxyglucose (2-[14C]DG) administration. The GIR is displayed as a time course commencing twenty minutes prior to administration of 2-[14C]DG (−20 minute time point) to 30 minutes following 2-[14C]DG infusion (30 minute time point). (b) Arterial, blood glucose concentration following 2-[14C]DG for 30 minutes post-administration. Data are mean ± SEM for n = 9-12 mice per group. *p < 0.05 vs. SHAM.