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Table 1 Baseline demographic data, echocardiographic characteristics, and adipose tissue measurements of the 149 patients undergoing peritoneal dialysis included in the study

From: Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis

 

No LVDD

LVDD

 

Baseline characteristics

(n = 84)

(n = 65)

p

Age (years)

53.4 ± 14.8

57.8 ± 11.7

0.035*

Women (%)

43 (51)

40 (62)

0.25

HTN (n)

50

56

<0.001*

DM (n)

23

25

0.16

Fasting plasma glucose (mg/dL)

96.2 ± 19.5

97.3 ± 11.8

0.69

HDL (mg/dL)

38.9 ± 8.3

41.7 ± 12.6

0.26

LDL (mg/dL)

83.2 ± 33.5

99.1 ± 38.0

0.05*

TG (mg/dL)

125.3 ± 85.3

142.4 ± 96.1

0.23

Height (cm)

163 ± 5.9

162 ± 6.5

0.30

Body weight (kg)

59 ± 10.5

60 ± 11.7

0.82

BMI (kg/m2)

23 ± 3.9

24 ± 3.2

0.46

CRP (mg/dL)

0.74 ± 0.99

2.13 ± 1.73

<0.001*

Primary renal diagnosis

   

DM

29

25

0.61

CGN

25

17

0.59

Other

30

23

0.87

Time on PD (h)

18.9 ± 1.6

19.1 ± 1.3

0.46

Kt/V

1.72 ± 0.34

1.91 ± 0.25

0.57

Residual renal function (mL/min)

1.94 ± 0.31

2.31 ± 0.22

0.25

Echocardiographic characteristics

LV end-diastolic diameter (mm)

48.4 ± 6.7

50.9 ± 7.4

0.03*

LV end-systolic diameter (mm)

30.4 ± 6.2

32.5 ± 8.1

0.04*

LA diameter (mm)

32.6 ± 6.5

37.3 ± 5.8

<0.001*

LV ejection fraction (%)

64.4 ± 7.9

66.2 ± 9.1

0.17

E (cm/s)

71.4 ± 20.0

89.4 ± 32.0

<0.001*

A (cm/s)

88.6 ± 20.2

104.8 ± 30.1

<0.001*

E/A

0.97 ± 0.46

0.77 ± 0.35

0.003*

DT (ms)

200.9 ± 45.2

238.7 ± 78.7

<0.001*

e’ (cm/s)

7.6 ± 2.4

5.7 ± 2.0

<0.001*

E/e’

10.2 ± 4.0

17.0 ± 8.1

<0.001*

LV mass index (g/cm3)

213.4 ± 63.9

245.3 ± 77.6

0.03*

EpF (mm)

2.8 ± 1.6

5.1 ± 2.6

<0.001*

Adipose tissue distribution

   

Total fat (cm2)

242.7 ± 87.2

335.0 ± 207.5

0.001*

Subcutaneous fat (cm2)

123.8 ± 60.6

170.2 ± 79.3

0.001*

Visceral fat (cm2)

89.3 ± 60.4

128.1 ± 77.1

0.006*

Peritoneal fat (cm2)

52.2 ± 45.9

88.5 ± 71.2

0.003*

Retroperitoneal fat (cm2)

385.0 ± 241.5

481.3 ± 289.1

0.07

  1. The data are presented as the mean ± standard deviation unless otherwise indicated.
  2. Abbreviations: LVDD left ventricular diastolic dysfunction; BMI body mass index; WC waist circumference; DM diabetes mellitus; CGN chronic glomerular nephritis; HTN hypertension; HOMA homeostasis model of insulin resistance; CRP C-reactive protein; LDL low density lipoprotein; HDL high density lipoprotein; TG triglyceride; PD peritoneal dialysis; kt/v, k = dialyzer clearance of urea, t = dialysis time, v = volume of distribution of urea, approximately equal to the patient’s total body water; LA left atrial; LV left ventricular; E mitral inflow E wave; A mitral inflow A wave; DT mitral inflow deceleration time; e’, peak annular early diastolic velocity of the lateral mitral annulus in tissue Doppler imaging; IVRT interventricular relaxation time; EpF epicardial fat. *, p < 0.05.