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Table 2 C-statistics and net reclassification improvement (NRI) for the conventional risk markers alone, and in combination with one or more novel risk marker

From: Interleukin-6 and activin A are independently associated with cardiovascular events and mortality in type 2 diabetes: the prospective Asker and Bærum Cardiovascular Diabetes (ABCD) cohort study

  Harrell’s C NRI, P-value
Standard (STD) model alone 0.794 Reference model
STD + IL-6 0.913 43.2%, p = 0.001
STD + log ActivinA 0.859 20.3%, p = 0.013
STD + IL-6 + log ActivinA 0.923 46.5%, p < 0.001
STD + E/Em + pathol recovery loop 0.891 21.5%, p = 0.099
  1. The NRI calculations are based on estimated probabilities of event from logistic regression models. The three risk categories used are defined by the probability cut-offs 5% and 10%.
  2. STD model: age, gender, known CVD, diastolic blood pressure, microalbuminuria and serum levels of HDL-cholesterol and creatinine
  3. Abbreviations: STD Standard, IL-6 Interleukin-6, pathol Pathological.